Scientists use ginger nanoparticles to heal inflammatory bowel disease

Scientists use ginger nanoparticles to heal inflammatory bowel disease

Here’s an interesting one – An article on ginger nanoparticles. The scientists at the Atlanta Veterans Affairs Medical Centre and Georgia State University in the US have developed a way to deliver ginger in the form of nanoparticles to offer a targeted remedy for inflammatory bowel disease. The study also suggested that nanoparticles may be useful in the fight against cancer linked to colitis.

“We characterized a specific population of nanoparticles derived from edible ginger (GDNPs 2) and demonstrated their efficient colon targeting following oral administration,” the authors wrote. “These nanoparticles contained high levels of lipids, a few proteins, 125 microRNAs (miRNAs), and large amounts of ginger bioactive constituents (6-gingerol and 6-shogaol). We also demonstrated that GDNPs 2 were mainly taken up by intestinal epithelial cells (IECs) and macrophages, and were nontoxic.”

Scientists have been experimenting with nanotechnology as a way to deliver drugs. The advantage of nanotechnology is that it can deliver low doses of drugs to specific areas, thereby bypassing unwanted effects on the rest of the body.

The article notes the therapeutic effects of ginger. The root of ginger has been used for thousands of years as a remedy for a variety of health issues, such as colds, arthritis, nausea, migraines, and hypertension. However, the researchers turned this spice into ginger-derived nanoparticles (GDNPs).

The article explains that to make the nanoparticles, Dr. Merlin of the Institute for Biomedical Sciences at Georgia State University and his team used a kitchen blender to start juicing fresh ginger root from the local farmers’ market. Next, a super-high-speed centrifuge was used to achieve ultrasonic dispersion of the ginger juice and create pellets.

Then each nanoparticle was about 230 nanometers in diameter, and over 300 of these nanoparticles could fit across the width of a human hair. The particles appeared to be nontoxic and had great therapeutic effects.

The article described the outcomes from the test on mouse models. The researchers found that the particles:

– Efficiently targeted the colon. They were absorbed mainly by cells in the lining of the intestines, where IBD inflammation occurs.

– Decreased acute colitis and block chronic colitis and colitis-associated cancer.

– Improved intestinal repair. Especially, they improved the survival and proliferation of the cells that make up the lining of the colon.

– Raised the levels of proteins that fight inflammation and lowered the production of proteins that promote inflammation.

The team concluded that delivering the ginger compounds in a nanoparticle is a more effective way of targeting colon tissue than eating natural ginger as a food or supplement.

To read the full article, click here.

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