Nanofibres developed for healing bone fractures

Nanofibres developed for healing bone fractures

We recently found an interesting article on nanofibre and its potential use for healing bone fractures that we thought might interest you.

Jani Holopainen, and his doctoral research at the Department of Chemistry at the University of Helsinki, indicates a future where it may be possible to use nanofibres to improve the attachment of bone implants, or be used directly to scaffold bone regeneration. This would aid the healing of fractures and may also enable the care of osteoporosis.

Holopainen has developed processes of fibrous and thin-film biomaterials. He also studied the apparatus used for nanofibre production.

Synthetic bone-like material

“At best, bone-reforming scaffolds that regenerate at the same rate as bones could be used as implants. The scaffolds activate the bone cells to generate new bone that slowly replaces the disintegrating scaffold and the implant exits the body naturally without separate removal surgery,” Jani Holopainen says.

Holopainen selected hydroxyapatite, which is the main component of bone mineral, as the focus of his research. This is why the synthetic hydroxyapatite structures are very compatible with bone.

Prototypes manufactured in Helsinki

Holopainen developed the electrospinning apparatus for producing hydroxyapatite fibers and a new kind of needleless twisted wire electrospinning setup, which is more productive than the generally known electrospinning method. The prototypes for the equipment used in the research were manufactured at the Department of Chemistry at the University of Helsinki. The equipment will have to be developed further in order to enhance production to an industrial scale.

“This promising method still has a long way to go before it will become a real medical application, though cellular tests have already been made,” says Professor Mikko Ritala of the Department of Chemistry and the Atomic Layer Deposition centre of excellence at the University of Helsinki, who was the advisor of the doctoral research.

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